MFSD8
Sign in to saveAlso known as CLN7, CCMD, major facilitator superfamily domain containing 8
Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the MFSD8 gene. MFSD8 is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 (AMTF2).
Gene data
MFSD8- Name
- major facilitator superfamily domain containing 8
- Type
- protein-coding
- Aliases
- CCMD, CLN7, SLC74A1
This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 115814
- exact match
- identifiers.org/ncbigene/256471
- genomic start
- 127917799
- genomic end
- 127966034
- cytogenetic location
- 4q28.2
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Article
5 sectionsContents
- Function
- Clinical significance
- References
- External links
- Further reading
Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the MFSD8 gene. MFSD8 is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 (AMTF2).
==Function== MFSD8 is a ubiquitous integral membrane protein which contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein, likely localizes to lysosomal membranes.