MFGE8
Sign in to saveAlso known as milk fat globule-EGF factor 8 protein, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S
Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.
In the Vinony graph
Vinony's link graph records 12 inbound references to MFGE8, and connects out to PubMed, human chromosome 15 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 15.
Vinony links it to 7 Wikipedia language editions.
Gene data
MFGE8- Name
- milk fat globule EGF and factor V/VIII domain containing
- Type
- protein-coding
- Position
- 88,898,683–88,913,579 (−)
- Aliases
- BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47
- Ensembl
- ENSG00000140545
- RefSeq RNA
- NM_001114614.3, NM_001310319.2, NM_001310320.2, NM_001310321.2, NM_005928.4
- RefSeq protein
- NP_001108086.1, NP_001297248.1, NP_001297249.1, NP_001297250.1, NP_005919.2
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
milk fat globule EGF and factor V/VIII domain containing
- Symbol
- MFGE8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:88,898,683-88,913,579
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- MFGE8.png
Show 7 more facts
- HomoloGene ID
- 4334
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4240
- chromosome
- human chromosome 15
- genomic start
- 89441916
- genomic end
- 88913468
- cytogenetic location
- 15q26.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Species distribution
- Function
- References
- Further reading
Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.
== Species distribution ==
Excerpted from Wikipedia’s “MFGE8” article, available under the CC BY-SA 4.0 licence.