MMP11

Also known as SL-3, ST3, STMY3, matrix metallopeptidase 11

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.

In the Vinony graph

Within Vinony's link graph, MMP11 is referenced by 147 other articles, and connects out to Q180686, Ensembl genome database project and enzyme.

It sits within the topics EC 3.4.24, Human genes and Matrix metalloproteinases.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MMP11

Name: matrix metallopeptidase 11
Type: protein-coding
Position: 23,768,226–23,784,322 (+)
Aliases: SL-3, ST3, STMY3
Ensembl: ENSG00000099953
RefSeq RNA: NM_005940.5, NR_133013.2
RefSeq protein: NP_005931.2

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008].