Bone morphogenetic protein 1

Protein · UniProt

Bone morphogenetic protein 1

Gene

BMP1

Organism

Homo sapiens (Human)

Length

986 aa

Molecular mass

111,249 Da

Evidence

1: Evidence at protein level

Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lys…

• Bone morphogenetic protein 1 as a macromolecular pan-cancer biomarker modulating the immune microenvironment and malignant phenotypes in glioblastoma.International journal of biological macromolecules · 2025
• The bone morphogenetic protein 1/Tolloid-like metalloproteinases.Matrix biology : journal of the International Society for Matrix Biology · 2007
• [Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
• Can Bone Morphogenetic Protein 1 (BMP1) Be a Potential Biomarker of Obesity?Cureus · 2024
• The matrix in cancer.Nature reviews. Cancer · 2021

via PubMed

• PHASE1/PHASE2NOT_YET_RECRUITING
  DIAG723 in Adults With Hereditary Hemorrhagic TelangiectasiaDiagonal Therapeutics, Inc. · NCT07623525
• PHASE1COMPLETED
  Study of Single-Ascending Doses of DS-6016a in Healthy Japanese SubjectsDaiichi Sankyo Co., Ltd. · NCT04818398
• NACOMPLETED
  Validation of New Therapeutic Targets to Prevent Collagen Accumulation During Cardiac Fibrosis: Procollagen C-proteinase EnhancersCentre Hospitalier Universitaire Dijon · NCT04820959

via ClinicalTrials.gov

Wikidata facts

Instance of

bone morphogenetic protein

via Wikidata · CC0