MMP16
Sign in to saveAlso known as C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16
Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.
Gene data
MMP16- Name
- matrix metallopeptidase 16
- Type
- protein-coding
- Position
- 88,032,011–88,328,025 (−)
- Aliases
- C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP
- Ensembl
- ENSG00000156103
- RefSeq RNA
- NM_005941.5, NM_022564.3, NM_032297.1, XM_024447154.2, XM_054360480.1
- RefSeq protein
- NP_005932.2, XP_024302922.1, XP_054216455.1
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
matrix metallopeptidase 16
- Symbol
- MMP16
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:88,032,011-88,328,025
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Excerpted from Wikipedia’s “MMP16” article, available under the CC BY-SA 4.0 licence.