MMP16

Also known as C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.

Gene data

MMP16

Name: matrix metallopeptidase 16
Type: protein-coding
Position: 88,032,011–88,328,025 (−)
Aliases: C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP
Ensembl: ENSG00000156103
RefSeq RNA: NM_005941.5, NM_022564.3, NM_032297.1, XM_024447154.2, XM_054360480.1
RefSeq protein: NP_005932.2, XP_024302922.1, XP_054216455.1

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010].

Pathways

Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Degradation of the extracellular matrix Extracellular matrix organization Activation of Matrix Metalloproteinases Signal Transduction Signaling by TGFB family members Signaling by TGFBR3 TGFBR3 PTM regulation Matrix Metalloproteinases

via MyGene.info

Gene · Ensembl

matrix metallopeptidase 16

Symbol: MMP16
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:88,032,011-88,328,025
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein MMP16 PDB 1rm8.png

Show 5 more facts

HomoloGene ID: 55939
exact match: identifiers.org/ncbigene/4325
genomic end: 89340254
genomic start: 88032011
cytogenetic location: 8q21.3

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Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.