Structure via PubChem · Public domain (PubChem)
monastrol
Sign in to saveMonastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity.
Chemical data
- Formula
- C14H16N2O3S
- Molecular weight
- 292.36 g/mol
- IUPAC name
- ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
- SMILES
- CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
- InChIKey
- LOBCDGHHHHGHFA-UHFFFAOYSA-N
- XLogP
- 1.6
- Polar surface area
- 103 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 292.088163
Show 4 more facts
- Commons category
- Monastrol
- canonical SMILES
- CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
- chemical formula
- C₁₄H₁₆N₂O₃S
- subject has role
- bactericide
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Mechanism of action
- References
Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known as KIF11, Kinesin Eg5), a motor protein important for spindle bipolarity.
==Mechanism of action== thumb|Monastrol inhibits Eg5 Monastrol binds to a long loop that is specific to the Eg5 (also known as KIF11 or kinesin-5) kinesin family, and allosterically inhibits ATPase activity of the kinesin
Excerpted from Wikipedia’s “monastrol” article, available under the CC BY-SA 4.0 licence.