MRPL17

Also known as L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17

gene umano

Gene data

MRPL17

Name: mitochondrial ribosomal protein L17
Type: protein-coding
Position: 6,680,364–6,683,411 (−)
Aliases: L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, bL17m
Ensembl: ENSG00000158042
RefSeq RNA: NM_022061.4
RefSeq protein: NP_071344.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].