MRPL4

Also known as CGI-28, L4mt, mitochondrial ribosomal protein L4

protein-coding gene in the species Homo sapiens

Gene data

MRPL4

Name: mitochondrial ribosomal protein L4
Type: protein-coding
Position: 10,251,901–10,260,060 (+)
Aliases: CGI-28, L4mt, uL4m
Ensembl: ENSG00000105364
RefSeq RNA: NM_001411149.1, NM_015956.3, NM_146387.2, NM_146388.2
RefSeq protein: NP_001398078.1, NP_057040.2, NP_666499.1, NP_666500.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008].