MRPS18A
Sign in to saveAlso known as HumanS18b, MRP-S18-3, MRPS18-3, S18bmt, mitochondrial ribosomal protein S18A, S18mt-a, MRP-S18-a
28S ribosomal protein S18a, mitochondrial is a protein that in humans is encoded by the MRPS18A gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to MRPS18A, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 6.
Vinony links it to 6 Wikipedia language editions.
Gene data
MRPS18A- Name
- mitochondrial ribosomal protein S18A
- Type
- protein-coding
- Position
- 43,669,978–43,687,954 (−)
- Aliases
- HumanS18b, MRP-S18-3, MRP-S18-a, MRPS18-3, S18bmt, S18mt-a, mL66
- Ensembl
- ENSG00000096080
- RefSeq RNA
- NM_001193343.2, NM_018135.4, XM_006715134.4, XM_054355773.1
- RefSeq protein
- NP_001180272.1, NP_060605.1, XP_006715197.1, XP_054211748.1
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mitochondrial ribosomal protein S18A
- Symbol
- MRPS18A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:43,669,978-43,687,954
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 32391
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55168
- genomic end
- 43655528
- genomic start
- 43671202
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
28S ribosomal protein S18a, mitochondrial is a protein that in humans is encoded by the MRPS18A gene.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p.
Excerpted from Wikipedia’s “MRPS18A” article, available under the CC BY-SA 4.0 licence.