MRPS24

Also known as MRP-S24, S24mt, bMRP-47, bMRP47, HSPC335, mitochondrial ribosomal protein S24

protein-coding gene in the species Homo sapiens

Gene data

MRPS24

Name: mitochondrial ribosomal protein S24
Type: protein-coding
Position: 43,866,556–43,869,893 (−)
Aliases: HSPC335, MRP-S24, S24mt, bMRP-47, bMRP47
Ensembl: ENSG00000062582
RefSeq RNA: NM_032014.3
RefSeq protein: NP_114403.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011].