MTF1
Sign in to saveAlso known as MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
gene umano
Gene data
MTF1- Name
- metal regulatory transcription factor 1
- Type
- protein-coding
- Position
- 37,809,574–37,859,614 (−)
- Aliases
- MTF-1, ZRF
- Ensembl
- ENSG00000188786
- RefSeq RNA
- NM_005955.3, XM_011541491.3, XM_011541493.4, XM_047421170.1, XM_047421173.1
- RefSeq protein
- NP_005946.2, XP_011539793.1, XP_011539795.1, XP_047277126.1, XP_047277129.1
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
RNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingcis-regulatory region sequence-specific DNA bindingcis-regulatory region sequence-specific DNA bindingDNA-binding transcription activator activity, RNA polymerase II-specificDNA-binding transcription activator activity, RNA polymerase II-specificDNA-binding transcription activator activity, RNA polymerase II-specific
Cellular component
Pathways
MetabolismRegulation of cholesterol biosynthesis by SREBP (SREBF)PPARA activates gene expressionActivation of gene expression by SREBF (SREBP)Regulation of lipid metabolism by PPARalphaMetabolism of lipidsMTF1 activates gene expressionMTF1 activates gene expressionResponse to metal ionsResponse to metal ions
via MyGene.info
Gene · Ensembl
metal regulatory transcription factor 1
- Symbol
- MTF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:37,809,574-37,859,614
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 4347
- genetic association
- hypothyroidism
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4520
- genomic end
- 37859592
- genomic start
- 37809574
- chromosome
- human chromosome 1
- cytogenetic location
- 1p34.3
- expressed in
- gums
via Wikidata · CC0