MX dynamin like GTPase 1
Sign in to saveAlso known as interferon-induced protein p78, myxoma resistance protein 1, Myxovirus resistance protein 1, interferon-regulated resistance GTP-binding protein MxA, IFI-78K, interferon-inducible protein p78, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78, MX1
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.
Protein · UniProt
Interferon-induced GTP-binding protein Mx1
- Gene
- MX1
- Organism
- Homo sapiens (Human)
- Length
- 662 aa
- Molecular mass
- 75,520 Da
- Evidence
- 1: Evidence at protein level
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 3 more facts
- biological process
- innate immune response
- exact match
- identifiers.org/uniprot:P20591
- found in taxon
- Homo sapiens
via Wikidata · CC0
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Encyclopedic overview
2 sectionsContents
- References
- Further reading
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.
In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.
Excerpted from Wikipedia’s “MX dynamin like GTPase 1” article, available under the CC BY-SA 4.0 licence.