MXI1
Sign in to saveAlso known as MAD2, MXD2, MXI, bHLHc11, MAX interactor 1, dimerization protein
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.
In the Vinony graph
Vinony's link graph records 812 inbound references to MXI1, and connects out to Q180686, human chromosome 10 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 10 and Transcription factors.
Vinony links it to 5 Wikipedia language editions.
Gene data
MXI1- Name
- MAX interactor 1, dimerization protein
- Type
- protein-coding
- Position
- 110,207,546–110,287,916 (+)
- Aliases
- MAD2, MXD2, MXI, bHLHc11
- Ensembl
- ENSG00000119950
- RefSeq RNA
- NM_001008541.1, NM_005962.5, NM_130439.3
- RefSeq protein
- NP_001008541.1, NP_005953.4, NP_569157.2
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
MAX interactor 1, dimerization protein
- Symbol
- MXI1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:110,207,546-110,287,916
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4351
- exact match
- identifiers.org/ncbigene/4601
- genomic start
- 111967363
- genomic end
- 112047123
- cytogenetic location
- 10q25.2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.
== Function ==
Excerpted from Wikipedia’s “MXI1” article, available under the CC BY-SA 4.0 licence.