MYD88

Also known as MYD88D, myeloid differentiation primary response 88, MYD88, innate immune signal transduction adaptor, MYD88 innate immune signal transduction adaptor, IMD68

Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene. originally discovered in the laboratory of Dan A. Liebermann (Lord et al. Oncogene 1990) as a Myeloid differentiation primary response gene.

In the Vinony graph

Within Vinony's link graph, MYD88 is referenced by 98 other articles, and connects out to TLR4, Q180686 and toll-like receptor.

It sits within the topics Genes mutated in mice, Genes on human chromosome 3 and Human proteins.

Its subject is documented across 9 Wikipedia language editions.

Gene data

MYD88

Name: MYD88 innate immune signal transduction adaptor
Type: protein-coding
Position: 38,138,552–38,143,024 (+)
Aliases: IMD68, MYD88D, WM1
Ensembl: ENSG00000172936
RefSeq RNA: NM_001172566.2, NM_001172567.2, NM_001172568.2, NM_001172569.3, NM_001365876.1
RefSeq protein: NP_001166037.2, NP_001166038.2, NP_001166039.2, NP_001166040.2, NP_001352805.1

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].