Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.
Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.
== Function == Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, which is highly conserved among all IRF proteins.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).