MYH7
Sign in to saveAlso known as CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin, heavy chain 7, cardiac muscle, beta, myosin heavy chain 7
Myosin-7 is a protein that in humans is encoded by the MYH7 gene.
Gene data
MYH7- Name
- myosin heavy chain 7
- Type
- protein-coding
- Aliases
- CMD1S, CMH1, CMYO7A, CMYO7B, CMYP7A, CMYP7B, MPD1, MYHCB, SPMD, SPMM
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy. [provided by RefSeq, May 2022].
via MyGene.info
Gene · Ensembl
myosin heavy chain 7
- Symbol
- MYH7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:23,412,732-23,436,137
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Interactions
- Clinical significance
- References
- Further reading
- External links
Myosin-7 is a protein that in humans is encoded by the MYH7 gene.
It is the myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers). This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament that forms the sarcomeres in cardiac muscle and plays a major role in cardiac muscle contraction.
Excerpted from Wikipedia’s “MYH7” article, available under the CC BY-SA 4.0 licence.