myriocin
Sign in to saveMyriocin, also known as antibiotic ISP-1 and thermozymocidin, is a non-proteinogenic amino acid derived from the entomopathogenic fungus, Isaria sinclairii.
Chemical data
- Formula
- C21H39NO6
- Molecular weight
- 401.5 g/mol
- IUPAC name
- (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
via PubChem
Research
537 papers- Myriocin enhances the clearance of M. tuberculosis by macrophages through the activation of PLIN2.mSphere · 2024
- Use of Myriocin as co-adjuvant in glaucoma surgery: An in vitro study.The international journal of biochemistry & cell biology · 2024
- Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway.Archives of pharmacal research · 2023
- Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis.Cellular signalling · 2021
- Myriocin Restores Metabolic Homeostasis in dAGE-Exposed Mice via AMPK-PGC1α-Mediated Mitochondrial Activation and Systemic Lipid/Glucose Regulation.Nutrients · 2025
via PubMed
Article
1 sectionsContents
- References
Myriocin, also known as antibiotic ISP-1 and thermozymocidin, is a non-proteinogenic amino acid derived from the entomopathogenic fungus, Isaria sinclairii.
Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids.