(S)-palmitoyl-CoA
Sign in to saveAlso known as Coenzyme A, S-hexadecanoate
Palmitoyl-CoA is an acyl-CoA thioester. It is an "activated" form of palmitic acid and can be transported into the mitochondrial matrix by the carnitine shuttle system (which transports fatty acyl-CoA molecules into mitochondria), and once inside, can participate in beta-oxidation. Alternatively, palmitoyl-CoA is used as a substrate in the biosynthesis of sphingosine (this biosynthetic pathway does not require transfer into mitochondria).
Research
2,337 papers- Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane.Cell reports · 2019
- Analogs of palmitoyl-CoA that are substrates for myristoyl-CoA:protein N-myristoyltransferase.Proceedings of the National Academy of Sciences of the United States of America · 1992
- Inhibition by palmitoyl CoA of dynein ATPase from sea urchin spermatozoa.Journal of biochemistry · 1982
- Palmitoyl-CoA potentiates the Ca2+ release elicited by cyclic ADP-ribose.The American journal of physiology · 1996
- The binding of palmitoyl-CoA to bovine serum albumin.Biochimica et biophysica acta · 1990
via PubMed
Article
6 sectionsContents
- Biosynthesis
- Beta-oxidation
- Sphingolipid biosynthesis
- Additional images
- See also
- References
{{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 386554704 | ImageFile = Palmitoyl coenzyme A.svg | ImageSize = 300px | IUPACName = 3′-O-Phosphonoadenosine 5′-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate} | SystematicName = O1-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl} O3-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} dihydrogen diphosphate | OtherNames = | Section1 = | Section2 = | Section3 = }}
Palmitoyl-CoA is an acyl-CoA thioester. It is an "activated" form of palmitic acid and can be transported into the mitochondrial matrix by the carnitine shuttle system (which transports fatty acyl-CoA molecules into mitochondria), and once inside, can participate in beta-oxidation. Alternatively, palmitoyl-CoA is used as a substrate in the biosynthesis of sphingosine (this biosynthetic pathway does not require transfer into mitochondria).