Structure via PubChem · Public domain (PubChem)
Ponesimod
Sign in to savePonesimod, sold under the brand name Ponvory, is a medication for the treatment of multiple sclerosis. It is a sphingosine-1-phosphate receptor modulator.
Chemical data
- Formula
- C23H25ClN2O4S
- Molecular weight
- 461 g/mol
- IUPAC name
- (5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one
- SMILES
- CCCN=C1N(C(=O)/C(=C/C2=CC(=C(C=C2)OC[C@@H](CO)O)Cl)/S1)C3=CC=CC=C3C
- InChIKey
- LPAUOXUZGSBGDU-ULCCENQXSA-N
- XLogP
- 4.6
- Polar surface area
- 108 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- psoriasis, multiple sclerosis, relapsing-remitting multiple sclerosis, chronic graft versus host disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 460.12235596
Show 4 more facts
- Commons category
- Ponesimod
- isomeric SMILES
- CCCN=C1S/C(=C\c2ccc(OC[C@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
- chemical formula
- C₂₃H₂₅ClN₂O₄S
- canonical SMILES
- CCCN=C1SC(=Cc2ccc(OCC(O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Adverse effects
- Mechanism of action
- History
- Clinical trials
- Society and culture
- Legal status
- References
Ponesimod, sold under the brand name Ponvory, is a medication for the treatment of multiple sclerosis. It is a sphingosine-1-phosphate receptor modulator.
The most common side effects include upper respiratory tract infection, hepatic transaminase elevation, and hypertension.
Excerpted from Wikipedia’s “Ponesimod” article, available under the CC BY-SA 4.0 licence.