Nanog homeobox
Sign in to saveAlso known as hNanog, homeobox transcription factor Nanog-delta 48, NANOG, homeobox protein NANOG, homeobox transcription factor Nanog, Nanog Homeobox Protein
transcriptional factor that helps embryonic stem cells maintain pluripotency by suppressing cell determination factors
Protein · UniProt
Homeobox protein NANOG
- Gene
- NANOG
- Organism
- Homo sapiens (Human)
- Length
- 305 aa
- Molecular mass
- 34,620 Da
- Evidence
- 1: Evidence at protein level
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]AT…
Swiss-Prot (reviewed) · via UniProt
Research
2,442 papers- Core transcriptional regulatory circuitry in human embryonic stem cells.Cell · 2005
- NANOG expression in human development and cancerogenesis.Experimental biology and medicine (Maywood, N.J.) · 2020
- Research progress of nanog gene in fish.Molecular genetics and genomics : MGG · 2024
- Disruption of NANOG-driven epithelial-mesenchymal transition (EMT) and self-renewal restores drug sensitivity in colorectal cancer.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
- Evolution of homeobox genes.Wiley interdisciplinary reviews. Developmental biology · 2013
via PubMed