Also known as MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc
MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.
Gene data
MYC- Name
- MYC proto-oncogene, bHLH transcription factor
- Type
- protein-coding
- Aliases
- MRTL, MYCC, bHLHe39, c-Myc
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].
via MyGene.info
Wikidata facts
- Image
- C-Myc-DNA complex.png
Show 5 more facts
- HomoloGene ID
- 31092
- exact match
- identifiers.org/ncbigene/4609
- genomic end
- 127742951
- genomic start
- 128747680
- cytogenetic location
- 8q24.21
Sources (4)
via Wikidata · CC0
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Article
4 sectionsContents
- Function
- As a drug target
- References
- Further reading
MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.
==Function==