MYC

Also known as MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.

Gene data

MYC

Name: MYC proto-oncogene, bHLH transcription factor
Type: protein-coding
Position: 127,735,434–127,742,951 (+)
Aliases: MRTL, MYCC, bHLHe39, c-Myc
Ensembl: ENSG00000136997
RefSeq RNA: NM_001354870.1, NM_002467.6
RefSeq protein: NP_001341799.1, NP_002458.2

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].

Gene Ontology

Biological process

G1/S transition of mitotic cell cycle negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade branching involved in ureteric bud morphogenesis positive regulation of mesenchymal cell proliferation chromatin remodeling regulation of DNA-templated transcription

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific core promoter sequence-specific DNA binding

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleus nucleus

Pathways

MAPK signaling pathway - Homo sapiens (human)ErbB signaling pathway - Homo sapiens (human)Cell cycle - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Wnt signaling pathway - Homo sapiens (human)TGF-beta signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)JAK-STAT signaling pathway - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

MYC proto-oncogene, bHLH transcription factor

Symbol: MYC
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:127,735,434-127,742,951
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: C-Myc-DNA complex.png

Show 7 more facts

HomoloGene ID: 31092
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4609
genomic end: 127742951
genomic start: 128747680
chromosome: human chromosome 8
cytogenetic location: 8q24.21

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

4 sections

Contents

Function
As a drug target
References
Further reading

==Function==

Excerpted from Wikipedia’s “MYC” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0

MYC