Neuropeptide Y

Chemical data

Drug data · ChEMBL

Molecule type

Protein

via ChEMBL · EBI

Protein · UniProt

Pro-neuropeptide Y

Gene

NPY

Organism

Homo sapiens (Human)

Length

97 aa

Molecular mass

10,851 Da

Evidence

1: Evidence at protein level

Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1321422, PubMed:7592910, PubMed:35165283, PubMed:35507650, PubMed:36525977, PubMed:38882210). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1321422, PubMed:7592910, PubMed:38882210). Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels (PubMed:1321422, PubMed:35165283, PubMed:7592910). Is involved in the regulation of eating behaviour, acting as a stimulator of food…

• Neuropeptide Y, resilience, and PTSD therapeutics.Neuroscience letters · 2017
• Neuropeptide Y and its Involvement in Chronic Pain.Neuroscience · 2018
• Neuropeptide Y: An Anti-Aging Player?Trends in neurosciences · 2015
• Neuropeptide Y family of hormones: receptor subtypes and antagonists.Peptides · 1997
• Neuropeptide Y is an angiogenic factor in cardiovascular regeneration.European journal of pharmacology · 2016

via PubMed

• COMPLETED
  Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed NeuroblastomaChildren's Oncology Group · NCT01387724
• EARLY_PHASE1COMPLETED
  Neuropeptide Y and Sympathovagal BalanceEric Grouzmann · NCT03933787
• PHASE4COMPLETED
  Effect of DPP4 Inhibition on VasoconstrictionVanderbilt University · NCT02639637
• PHASE1COMPLETED
  A Dose Escalation Study of Intranasal Neuropeptide Y in Post Traumatic Stress Disorder (PTSD)James Murrough · NCT01533519
• NANOT_YET_RECRUITING
  Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial ProtocolDexiong Han · NCT06990854
• PHASE4COMPLETED
  Moxonidine Effects on Neuropeptide YAristotle University Of Thessaloniki · NCT05147753

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0