NFATC4
Sign in to saveAlso known as NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.
Gene data
NFATC4- Name
- nuclear factor of activated T cells 4
- Type
- protein-coding
- Position
- 24,365,673–24,379,613 (+)
- Aliases
- NF-AT3, NF-ATC4, NFAT3
- Ensembl
- ENSG00000100968
- RefSeq RNA
- NM_001136022.3, NM_001198965.2, NM_001198966.2, NM_001198967.3, NM_001288802.2
- RefSeq protein
- NP_001129494.1, NP_001185894.1, NP_001185895.1, NP_001185896.1, NP_001275731.1
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nuclear factor of activated T cells 4
- Symbol
- NFATC4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:24,365,673-24,379,613
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.
== Function ==
Excerpted from Wikipedia’s “NFATC4” article, available under the CC BY-SA 4.0 licence.