NFYA
Sign in to saveAlso known as CBF-A, CBF-B, HAP2, NF-YA, nuclear transcription factor Y subunit alpha
Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.
Gene data
NFYA- Name
- nuclear transcription factor Y subunit alpha
- Type
- protein-coding
- Position
- 41,072,040–41,103,063 (+)
- Aliases
- CBF-A, CBF-B, HAP2, NF-YA
- Ensembl
- ENSG00000001167
- RefSeq RNA
- NM_002505.5, NM_021705.4
- RefSeq protein
- NP_002496.1, NP_068351.1
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nuclear transcription factor Y subunit alpha
- Symbol
- NFYA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:41,072,040-41,103,063
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 32114
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4800
- genomic end
- 41102403
- genomic start
- 41072974
- expressed in
- monocyte
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.1
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- Structure
- References
- Further reading
- External links
Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.
== Function == The protein encoded by this gene is one subunit of a trimeric complex NF-Y, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit NFYA associates with a tight dimer composed of the NFYB and NFYC subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the NFYA subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
Excerpted from Wikipedia’s “NFYA” article, available under the CC BY-SA 4.0 licence.