NINJ1
Sign in to saveAlso known as NIN1, NINJURIN, ninjurin 1
Ninjurin-1 is a protein encoded by the NINJ1 gene in humans. This transmembrane protein plays a critical role in plasma membrane rupture during lytic cell death. NINJ1 is involved in the terminal stages of cell rupture across various cell death pathways, including pyroptosis, necroptosis, and ferroptosis. By disrupting cell membranes, NINJ1 facilitates the release of intracellular proteins, such as lactate dehydrogenase and various Damage Associated Molecular Patterns (DAMPs) into the extracellular environment, triggering inflammation. Upon activation, NINJ1 assembles into a chain-like oligome
Gene data
NINJ1- Name
- ninjurin 1
- Type
- protein-coding
- Aliases
- NIN1, NINJURIN, hNINJ1
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009].
via MyGene.info
Gene · Ensembl
ninjurin 1
- Symbol
- NINJ1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:93,121,495-93,134,612
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 88815
- genomic start
- 93121496
- exact match
- identifiers.org/ncbigene/4814
- genomic end
- 93134251
- cytogenetic location
- 9q22.31
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Gene
- Clinical Significance
- References
- Further reading
Ninjurin-1 is a protein encoded by the NINJ1 gene in humans. This transmembrane protein plays a critical role in plasma membrane rupture during lytic cell death. NINJ1 is involved in the terminal stages of cell rupture across various cell death pathways, including pyroptosis, necroptosis, and ferroptosis. By disrupting cell membranes, NINJ1 facilitates the release of intracellular proteins, such as lactate dehydrogenase and various Damage Associated Molecular Patterns (DAMPs) into the extracellular environment, triggering inflammation. Upon activation, NINJ1 assembles into a chain-like oligomer that forms a ring structure—dubbed the "Ninja Cutter"—which, like a cookie cutter, cuts and releases membrane disks, enabling cell rupture.
== Gene == NINJ1 is located on the long arm of chromosome 9 (9q22.31).