nintedanib
Sign in to saveAlso known as BIBF-1120, BIBF1120, Ofev®, Vargatef®, BIBF 1120, methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 428116657
- Drug.image
- Nintedanib.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Nintedanib
- Drug.caption
- Nintedanib
- Drug.tradename
- Vargatef, Ofev
- Drug.MedlinePlus
- a615009
- Drug.DailyMedID
- Nintedanib
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- EX09
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Wikidata facts
- Mass
- 539.253
- Official website
- www.ofev.com
- Has use
- medication
Show 6 more facts
- subject has role
- enzyme inhibitor
- chemical formula
- C₃₁H₃₃N₅O₄
- canonical SMILES
- CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5
- isomeric SMILES
- CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5
- World Health Organisation international non-proprietary name
- nintedanib
- Commons category
- Nintedanib
Sources (7)
via Wikidata · CC0
~15 min read
Encyclopedic overview
20 sectionsContents
- Medical uses
- Idiopathic pulmonary fibrosis
- Lung cancer
- Contraindications
- Adverse effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Interactions
- Chemistry
- History
- Idiopathic pulmonary fibrosis
- Lung cancer
- Other interstitial lung diseases
- Society and culture
- Legal status
- Brand names
- Research
- Breast cancer
- References
{{Infobox drug | Verifiedfields = changed | verifiedrevid = 428116657 | image = Nintedanib.svg | image_class = skin-invert-image | width = | alt = Nintedanib | caption = Nintedanib
| pronounce = | tradename = Vargatef, Ofev | Drugs.com = | MedlinePlus = a615009 | DailyMedID = Nintedanib | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATC_prefix = L01 | ATC_suffix = EX09 | ATC_supplemental =
Excerpted from Wikipedia’s “nintedanib” article, available under the CC BY-SA 4.0 licence.