NOBOX
Sign in to saveAlso known as OG-2, OG2, OG2X, POF5, TCAG_12042, NOBOX oogenesis homeobox
Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene. The official symbol (NOBOX) and the official full name (NOBOX oogenesis homeobox) are maintained by the HGNC. The NOBOX gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat. There are 175 organisms that have orthologs with human gene NOBOX. It is capable of regulating other genes that are important in the development of follicles. Follicles do not develop and oocytes decrease in its absence which lead to infertility.
Gene data
NOBOX- Name
- NOBOX oogenesis homeobox
- Type
- protein-coding
- Position
- 144,396,894–144,403,795 (−)
- Aliases
- OG-2, OG2, OG2X, POF5, TCAG_12042
- Ensembl
- ENSG00000106410
- RefSeq RNA
- NM_001080413.3, NM_001436401.1, NM_001436402.1, XM_017011742.3, XM_054332178.1
- RefSeq protein
- NP_001073882.3, NP_001423330.1, NP_001423331.1, XP_016867231.1, XP_054188153.1
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
NOBOX oogenesis homeobox
- Symbol
- NOBOX
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:144,396,894-144,403,795
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 51066
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/135935
- chromosome
- human chromosome 7
- genomic start
- 144094333
- genomic end
- 144107320
- cytogenetic location
- 7q35
- genetic association
- premature ovarian failure
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Discovery
- Gene location
- Protein structure
- Function
- Mutations and clinical significance
- Interactions
- References
- Further reading
Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene. The official symbol (NOBOX) and the official full name (NOBOX oogenesis homeobox) are maintained by the HGNC. The NOBOX gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat. There are 175 organisms that have orthologs with human gene NOBOX. It is capable of regulating other genes that are important in the development of follicles. Follicles do not develop and oocytes decrease in its absence which lead to infertility.
== Discovery == NOBOX is an in silico subtraction discovery when Suzumori et al. searched for novel genes involved in early mammalian folliculogenesis in 2002. It is one of the several genes that appeared in the search in expressed sequence tag (EST) databases of mouse. It was then cloned and characterised for its genomic structure.
Excerpted from Wikipedia’s “NOBOX” article, available under the CC BY-SA 4.0 licence.