NPRL2

Also known as NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.

In the Vinony graph

Vinony's link graph records 7 inbound references to NPRL2, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 3.

Vinony links it to 5 Wikipedia language editions.

Gene data

NPRL2

Name: NPR2 like, GATOR1 complex subunit
Type: protein-coding
Position: 50,347,330–50,350,826 (−)
Aliases: FFEVF2, NPR2, NPR2L, TUSC4
Ensembl: ENSG00000114388
RefSeq RNA: NM_006545.5, XM_011533288.4, XM_017005556.3, XM_047447310.1, XM_047447311.1
RefSeq protein: NP_006536.3, XP_011531590.1, XP_016861045.1, XP_047303266.1, XP_047303267.1

Enables protein kinase activity. Contributes to GTPase activator activity. Involved in cellular response to amino acid starvation; negative regulation of TOR signaling; and negative regulation of kinase activity. Located in lysosomal membrane. Part of GATOR1 complex. Implicated in focal epilepsy. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

negative regulation of kinase activity cellular response to amino acid starvation cellular response to amino acid starvation cellular response to amino acid starvation cellular response to amino acid starvation negative regulation of TORC1 signaling negative regulation of TORC1 signaling negative regulation of TORC1 signaling

Molecular function

GTPase activator activity protein binding

Cellular component

lysosomal membrane lysosomal membrane lysosomal membrane lysosomal membrane vacuolar membrane GATOR1 complex GATOR1 complex GATOR1 complex

Pathways

mTOR signaling pathway - Homo sapiens (human)Cellular responses to stress Cellular responses to stimuli Amino acids regulate mTORC1 Cellular response to starvation 22q11.2 copy number variation syndrome

via MyGene.info

Gene · Ensembl

NPR2 like, GATOR1 complex subunit

Symbol: NPRL2
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:50,347,330-50,350,826
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 4771
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10641
genomic end: 50350826
genomic start: 50384761
chromosome: human chromosome 3
cytogenetic location: 3p21.31

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.

== References ==

Excerpted from Wikipedia’s “NPRL2” article, available under the CC BY-SA 4.0 licence.