KIR2DL1

Name

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1

Type

protein-coding

Position

54,769,793–54,784,332 (+)

Aliases

CD158A, KIR-K64, KIR221, NKAT, NKAT-1, NKAT1, p58.1

Ensembl

ENSG00000278495

RefSeq RNA

NM_014218.3, XM_054331236.1

RefSeq protein

NP_055033.2, XP_054187211.1

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1

Symbol

KIR2DL1

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR19KIR_RSH_A_HAP_CTG3_1:85,097-99,353

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein KIR2DL1 PDB 1b6u.png

via Wikidata · CC0