NR1H4
Sign in to saveAlso known as BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4, PFIC5
protein-coding gene in the species Homo sapiens
Gene data
NR1H4- Name
- nuclear receptor subfamily 1 group H member 4
- Type
- protein-coding
- Aliases
- BAR, FXR, HRR-1, HRR1, PFIC5, RIP14
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016].
via MyGene.info
Gene · Ensembl
nuclear receptor subfamily 1 group H member 4
- Symbol
- NR1H4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:100,455,070-100,564,414
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Research
325 papers- NR1H4 ameliorates Parkinson's disease via inhibiting astrocyte activation and neuroinflammation in a CEBPβ/NF-κB dependent manner.International immunopharmacology · 2024
- Progressive Familial Intrahepatic Cholestasis.Clinics in liver disease · 2018
- NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death.Orphanet journal of rare diseases · 2024
- The ménage à trois of autophagy, lipid droplets and liver disease.Autophagy · 2022
- Liver-specific Nr1h4 deletion in mice with human-like bile acid composition causes severe liver injury.Journal of lipid research · 2025
via PubMed