NR3C1

Name

nuclear receptor subfamily 3 group C member 1

Type

protein-coding

Position

143,277,931–143,435,512 (−)

Aliases

GCCR, GCR, GCRST, GR, GRL

Ensembl

ENSG00000113580

RefSeq RNA

NM_000176.3, NM_001018074.1, NM_001018075.1, NM_001018076.2, NM_001018077.1

RefSeq protein

NP_000167.1, NP_001018084.1, NP_001018085.1, NP_001018086.1, NP_001018087.1

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011].

via MyGene.info

Gene · Ensembl

nuclear receptor subfamily 3 group C member 1

Symbol

NR3C1

Biotype

Protein coding

Organism

Homo sapiens

Location

5:143,277,931-143,435,512

Strand

Reverse (−)

Assembly

GRCh38