Gene data
NTF3- Name
- neurotrophin 3
- Type
- protein-coding
- Position
- 5,432,088–5,521,536 (+)
- Aliases
- HDNF, NGF-2, NGF2, NT-3, NT3
- Ensembl
- ENSG00000185652
- RefSeq RNA
- NM_001102654.2, NM_002527.5, XM_011520963.3, XM_047428901.1, XM_054372132.1
- RefSeq protein
- NP_001096124.1, NP_002518.1, XP_011519265.1, XP_047284857.1, XP_054228107.1
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
positive regulation of receptor internalizationsignal transductioncell surface receptor protein tyrosine kinase signaling pathwaycell surface receptor protein tyrosine kinase signaling pathwaycell-cell signalingnervous system developmentpositive regulation of cell population proliferationnerve development
Molecular function
Pathways
MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)PIP3 activates AKT signalingSignal TransductionSignal TransductionDiseaseSignaling by NTRKsSignaling by NTRKs
via MyGene.info
Gene · Ensembl
neurotrophin 3
- Symbol
- NTF3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:5,432,088-5,521,536
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein NTF3 PDB 1b8k.png
Show 7 more facts
- HomoloGene ID
- 1896
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4908
- genomic end
- 5630702
- genomic start
- 5432108
- chromosome
- human chromosome 12
- cytogenetic location
- 12p13.31
via Wikidata · CC0