Oncostatin M

Protein · UniProt

Oncostatin-M

Gene

OSM

Organism

Homo sapiens (Human)

Length

252 aa

Molecular mass

28,484 Da

Evidence

1: Evidence at protein level

Functions as a cytokine that uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (PubMed:10997905, PubMed:39532904, PubMed:8999038). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:10997905, PubMed:1542792, PubMed:1542793, PubMed:1717982, PubMed:2779549, PubMed:3540948). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with LIFR or OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesse…

• Oncostatin M.Progress in growth factor research · 1992
• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.Nature medicine · 2017
• Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts.Inflammatory bowel diseases · 2024
• Oncostatin M, a multifunctional cytokine.Reviews of physiology, biochemistry and pharmacology · 2003
• Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies.Signal transduction and targeted therapy · 2025

via PubMed

• NACOMPLETED
  Exercise-Induced Changes in Serum Oncostatin M Levels in Recreationally Active MalesHacettepe University · NCT07195630
• NANOT_YET_RECRUITING
  The Diagnostic Value of Serum Oncostatin M and Galactin 3 as Biomarkers in Diagnosis of Ulcerative Colitis DiseaseSohag University · NCT06959654
• NACOMPLETED
  Chlorhexidine and Zinc in Non-Surgical Periodontal TherapyAtaturk University · NCT07517991
• NACOMPLETED
  Measurement of Oncostatin M, Leukemia Inhibitory Factor and Interleukin-11 Levels of Patients With Periodontal DiseaseAtaturk University · NCT04597073
• PHASE2WITHDRAWN
  Study to Evaluate Safety, Tolerability and Efficacy of GSK2330811 in Crohn's DiseaseGlaxoSmithKline · NCT04151225
• NAUNKNOWN
  Study of the Role of Oncostatin M in Head and Neck Squamous Cell CarcinomaPoitiers University Hospital · NCT06199947

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Image

OncostatinM Crystal Structure.rsh.png

via Wikidata · CC0