Also known as PAL, PHM, Peptidylglycine alpha-amidating monooxygenase
protein-coding gene in the species Homo sapiens
Gene data
PAM- Name
- peptidylglycine alpha-amidating monooxygenase
- Type
- protein-coding
- Position
- 102,753,981–103,031,149 (+)
- Aliases
- PAL, PAM-1, PHM
- Ensembl
- ENSG00000145730
- RefSeq RNA
- NM_000919.4, NM_001177306.2, NM_001319943.1, NM_001364582.2, NM_001364583.2
- RefSeq protein
- NP_000910.2, NP_001170777.1, NP_001306872.1, NP_001351511.1, NP_001351512.1
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
peptidylglycine alpha-amidating monooxygenase
- Symbol
- PAM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:102,753,981-103,031,149
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI