proopiomelanocortin
Also known as corticotropin-lipotropin precursor, POMC(1-241), proopiomelanocortin preproprotein, corticotropin-like intermediary peptide, POMC, opiomelanocortin prepropeptide, pro-opiomelanocortin
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. POMC is part of the central melanocortin system.
Key facts
- Protein family.Symbol
- Op_neuropeptide
- Protein family.Name
- Opioids neuropeptide
- Protein family.Pfam
- PF08035
- Protein family.InterPro
- IPR013532
- Protein family.PROSITE
- PDOC00964
via Wikipedia infobox
Article
14 sectionsContents
- Gene
- Tissue distribution
- Function
- Post-translational modifications
- Derivatives
- Regulation by the photoperiod
- Clinical significance
- Drug target
- Dogs
- Interactions
- See also
- References
- Further reading
- External links
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. POMC is part of the central melanocortin system.
== Gene == The POMC gene is located on chromosome 2p23.3. This gene encodes a 285-amino acid polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases.