parvalbumin
Sign in to saveAlso known as parvalbumin alpha, PVALB
Parvalbumin (PV) is a calcium-binding protein with low molecular weight (typically 9–11 kDa). In humans, it is encoded by the PVALB gene. It is a member of the albumin family; it is named for its size (parv-, from Latin '''' which means "small") and its ability to coagulate.
Protein · UniProt
Parvalbumin alpha
- Gene
- PVALB
- Organism
- Homo sapiens (Human)
- Length
- 110 aa
- Molecular mass
- 12,059 Da
- Evidence
- 1: Evidence at protein level
In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (PubMed:15122922, PubMed:39584689)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- PHASE2COMPLETEDFAST Fish Phase IIb Clinical Trial for the Treatment of Fish Allergy by Subcutaneous ImmunotherapyGeorge Stavroulakis · NCT02382718
~6 min read
Encyclopedic overview
11 sectionsContents
- Structure
- Tissue distribution
- In neural tissue
- In muscular tissue
- Function
- Clinical significance
- Evolution
- History
- See also
- References
- External links
Parvalbumin (PV) is a calcium-binding protein with low molecular weight (typically 9–11 kDa). In humans, it is encoded by the PVALB gene. It is a member of the albumin family; it is named for its size (parv-, from Latin '''' which means "small") and its ability to coagulate.
It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is found in fast-contracting muscles, where its levels are highest, as well as in the brain and some endocrine tissues.
Excerpted from Wikipedia’s “parvalbumin” article, available under the CC BY-SA 4.0 licence.