peroxiredoxins
Sign in to saveAlso known as thiol-containing-reductant:hydroperoxide oxidoreductase, Prx, PRDX, peroxiredoxin
Peroxiredoxins (Prxs, ; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). Their function is the reduction of peroxides, specifically hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite.
Key facts
- Protein family.Symbol
- AhpC-TSA
- Protein family.Name
- AhpC-TSA
- Protein family.image
- Peroxiredoxin.png
- Protein family.caption
- Structure of AhpC, a bacterial 2-cysteine peroxiredoxin from Salmonella typhimurium.
- Protein family.Pfam
- PF00578
- Protein family.Pfam_clan
- CL0172
- Protein family.InterPro
- IPR000866
- Protein family.SCOP
- 1prx
- Protein family.OPM family
- 131
- Protein family.OPM protein
- 1xvw
- Enzyme.Name
- peroxiredoxin
- Enzyme.EC_number
- 1.11.1.15
- Enzyme.CAS_number
- 207137-51-7
- Enzyme.GO_code
- 0051920
via Wikipedia infobox
~6 min read
Encyclopedic overview
8 sectionsContents
- Classification
- Peroxiredoxin-like
- Catalytic cycle
- Enzyme regulation
- Function
- Circadian clock
- See also
- References
Peroxiredoxins (Prxs, ; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). Their function is the reduction of peroxides, specifically hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite.
== Classification ==
Excerpted from Wikipedia’s “peroxiredoxins” article, available under the CC BY-SA 4.0 licence.