PFDN1

Also known as PDF, PFD1, prefoldin subunit 1

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to PFDN1, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 7 Wikipedia language editions.

Gene data

PFDN1

Name: prefoldin subunit 1
Type: protein-coding
Position: 140,234,986–140,303,119 (−)
Aliases: PDF, PFD1
Ensembl: ENSG00000113068
RefSeq RNA: NM_002622.5, XM_005268465.5, XM_054352822.1
RefSeq protein: NP_002613.2, XP_005268522.1, XP_054208797.1

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

protein folding protein folding protein folding protein folding protein stabilization negative regulation of amyloid fibril formation

Molecular function

amyloid-beta binding protein binding protein folding chaperone protein folding chaperone unfolded protein holdase activity

Cellular component

cytoplasm prefoldin complex prefoldin complex prefoldin complex protein folding chaperone complex

Pathways

Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding Protein folding Metabolism of proteins Cellular Proteostasis

via MyGene.info

Gene · Ensembl

prefoldin subunit 1

Symbol: PFDN1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:140,234,986-140,303,119
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5201
HomoloGene ID: 37644
genomic end: 140303113
genomic start: 140245035
chromosome: human chromosome 5
cytogenetic location: 5q31.3

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled coils.

Excerpted from Wikipedia’s “PFDN1” article, available under the CC BY-SA 4.0 licence.