PHLDA1

Also known as DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to PHLDA1, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Vinony links it to 5 Wikipedia language editions.

Gene data

PHLDA1

Name: pleckstrin homology like domain family A member 1
Type: protein-coding
Position: 76,025,447–76,032,560 (−)
Aliases: DT1P1B11, PHRIP, TDAG51
Ensembl: ENSG00000139289
RefSeq RNA: NM_007350.3
RefSeq protein: NP_031376.3

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

positive regulation of apoptotic process positive regulation of apoptotic process

Molecular function

protein binding phosphatidylinositol phosphate binding

Cellular component

nucleus nucleolus nucleolus cytoplasm cytoplasm cytosol cytoplasmic vesicle cytoplasmic vesicle

Pathways

Cell Cycle Epigenetic regulation of gene expression Mitotic G2-G2/M phases G2/M Transition Cell Cycle, Mitotic Gene expression (Transcription)Interaction between PHLDA1 and AURKA Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes

via MyGene.info

Gene · Ensembl

pleckstrin homology like domain family A member 1

Symbol: PHLDA1
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:76,025,447-76,032,560
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 7203
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/22822
genomic end: 76031776
genomic start: 76419227
chromosome: human chromosome 12
cytogenetic location: 12q21.2

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.

Excerpted from Wikipedia’s “PHLDA1” article, available under the CC BY-SA 4.0 licence.