Structure via PubChem · Public domain (PubChem)
فیفالائمین
Sign in to saveAlso known as H-Pyr-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, XADPNKFYGLM
Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.
Chemical data
- Formula
- C58H84N14O16S
- Molecular weight
- 1265.4 g/mol
- IUPAC name
- (3S)-4-[(2S)-2-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxo-3-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]butanoic acid
- SMILES
- C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@@H]4CCC(=O)N4
- InChIKey
- SHSUJLMLURFKID-YFUSJSQUSA-N
- XLogP
- -4.2
- Polar surface area
- 506 Ų
- H-bond donors
- 15
- H-bond acceptors
- 18
- Formal charge
- 0
via PubChem
Research
479 papers- Conformation of physalaemin.European journal of biochemistry · 1984
- Synthesis of physalaemin.Experientia · 1964
- Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus.European journal of pharmacology · 2010
- The ontogeny of the antidipsogenic effect of eledoisin and physalaemin in the rat.Appetite · 1987
- The tachykinins neurokinin A and physalaemin stimulate murine thymocyte proliferation.International archives of allergy and applied immunology · 1989
via PubMed
Wikidata facts
- Mass
- 1264.5910436079998
Show 4 more facts
- chemical formula
- C₅₈H₈₄N₁₄O₁₆S
- canonical SMILES
- CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C3CCCN3C(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C4CCC(=O)N4
- isomeric SMILES
- C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@@H]4CCC(=O)N4
- subject has role
- neurotransmitter
Sources (1)
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