phytohaemagglutinin
Sign in to saveAlso known as phytohemagglutinin, PHA
Phytohaemagglutinin (PHA, or phytohemagglutinin) is a lectin found in plants, especially certain legumes. PHA actually consists of two closely related proteins, called leucoagglutinin (PHA-L) and PHA-E. These proteins cause blood cells to clump together. PHA-E cause erythrocytes (red blood cells) to clump. PHA-L causes leukocytes (white blood cells) to clump. Phytohaemagglutinin has carbohydrate-binding specificity for a complex oligosaccharide containing galactose, N-acetylglucosamine, and mannose.
Key facts
- Protein family.Symbol
- Lectin_legB
- Protein family.Name
- Legume lectin domain
- Protein family.image
- phytohemagglutinin L.png
- Protein family.caption
- Crystal structure of PHA-L (PDB 1fat)
- Protein family.Pfam
- PF00139
- Protein family.Pfam_clan
- CL0004
- Protein family.InterPro
- IPR001220
- Protein family.PROSITE
- PDOC00278
- Protein family.SCOP
- 1lem
via Wikipedia infobox
Research
23,119 papers- PHYTOHAEMAGGLUTININ.Lancet (London, England) · 1964
- PROPERTIES OF PHYTOHAEMAGGLUTININ.Nature · 1964
- Immunosuppression and phytohaemagglutinin.Lancet (London, England) · 1967
- Phytohaemagglutinin responsiveness of non-adherent nude spleen cells.Scandinavian journal of immunology · 1979
- Infiltrating gamma delta T-cells and selectin endothelial ligands in the cutaneous phytohaemagglutinin-induced inflammatory reaction.Veterinary immunology and immunopathology · 1994
via PubMed
Wikidata facts
- Subclass of
- hemagglutinin
Show 1 more fact
- Commons category
- Phytohemagglutinins
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Toxicity
- Uses
- Lymphocyte division
- Neuron tracing
- History
- References
- External links
Phytohaemagglutinin (PHA, or phytohemagglutinin) is a lectin found in plants, especially certain legumes. PHA actually consists of two closely related proteins, called leucoagglutinin (PHA-L) and PHA-E. These proteins cause blood cells to clump together. PHA-E cause erythrocytes (red blood cells) to clump. PHA-L causes leukocytes (white blood cells) to clump. Phytohaemagglutinin has carbohydrate-binding specificity for a complex oligosaccharide containing galactose, N-acetylglucosamine, and mannose.
PHA is found in the highest concentrations in uncooked red kidney beans (Phaseolus vulgaris) and another variety of Phaseolus vulgaris, white kidney beans (also known as cannellini), and it is also found in lower quantities in many other types of common green beans, such as broad beans (Vicia faba) also known as fava beans. PHA has a number of physiological effects and is used in medical research. In high doses, it is a toxin.
Excerpted from Wikipedia’s “phytohaemagglutinin” article, available under the CC BY-SA 4.0 licence.