CLEC10A
Sign in to saveAlso known as CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A, C-type lectin domain containing 10A
C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c+ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.
Gene data
CLEC10A- Name
- C-type lectin domain containing 10A
- Type
- protein-coding
- Position
- 7,074,537–7,081,166 (−)
- Aliases
- CD301, CLECSF13, CLECSF14, DC-ASGPR, HML, HML2, MGL
- Ensembl
- ENSG00000132514
- RefSeq RNA
- NM_001330070.2, NM_006344.4, NM_182906.4, XM_011523613.2, XM_011523615.2
- RefSeq protein
- NP_001316999.1, NP_006335.2, NP_878910.1, XP_011521915.1, XP_011521917.1
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
C-type lectin domain containing 10A
- Symbol
- CLEC10A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:7,074,537-7,081,166
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 7836
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10462
- genomic end
- 6983626
- genomic start
- 6977856
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.1
- expressed in
- testicle
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c+ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.
== Function ==
Excerpted from Wikipedia’s “CLEC10A” article, available under the CC BY-SA 4.0 licence.