Research
134,896 papers- Interplay between platelets and coagulation.Blood reviews · 2021
- Energy metabolism in platelets fuels thrombus formation: Halting the thrombosis engine with small-molecule modulators of platelet metabolism.Metabolism: clinical and experimental · 2023
- Isorhynchophylline Inhibits Platelet Activation and Thrombus Formation.Journal of cardiovascular pharmacology · 2025
- STK10 regulates platelet function in arterial thrombosis and thromboinflammation.Blood · 2026
- Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.Circulation · 2020
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- purl.obolibrary.org/obo/GO_0030220
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- Thrombopoiesis
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Article
4 sectionsContents
- Platelets
- Megakaryocytes
- Thrombopoietin
- References
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Thrombopoiesis is the formation of thrombocytes (blood platelets) in the bone marrow. Thrombopoietin is the main regulator of thrombopoiesis. Thrombopoietin affects most aspects of the production of platelets. This includes self-renewal and expansion of hematopoietic stem cells, stimulating the increase of megakaryocyte progenitor cells, and supporting these cells so they mature to become platelet-producing cells. The process of thrombopoiesis is caused by the breakdown of proplatelets (mature megakaryocyte membrane pseudopodial projections). During the process almost all of the membranes, organelles, granules, and soluble macromolecules in the cytoplasm are being consumed. Apoptosis also plays a role in the final stages of thrombopoiesis by letting proplatelet processes to occur from the cytoskeleton of actin.