
Also known as glomerular visceral epithelial cell, podocytes, glomerular podocyte, glomerular podocyte cell, epithelial cell of visceral layer of glomerular capsule
Podocytes are cells in Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus. Podocytes make up the epithelial lining of Bowman's capsule, the third layer through which filtration of blood takes place. Bowman's capsule filters the blood, retaining large molecules such as proteins while smaller molecules such as water, salts, and sugars are filtered as the first step in the formation of urine. Although various viscera have epithelial layers, the name visceral epithelial cells usually refers specifically to podocytes, which are specialized epithelial cells that reside in
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足細胞(podocyte、或"內臟上皮細胞"(visceral epithelial cell))為位於腎臟鮑氏囊上環繞着腎小球毛細血管之細胞。 鮑氏囊過濾血液,阻礙大分子,如蛋白質、紅血球、血小板;並通過小分子,如水、鹽及糖,進一步形成尿液。 足細胞的長足突或"足突出部分"環繞着毛細血管,介於足突之間留有裂隙。血液濾過這些裂隙,每個裂隙稱為裂隙隔膜(slit diaphragm)或濾過裂隙。足突出部分需要幾種蛋白質(腎病蛋白、NEPH1、NEPH2、足蛋白、CD2AP)環繞着毛細管及運作。當嬰兒出生時,這些蛋白質存在着一定的缺陷,諸如"腎病蛋白"及"CD2AP",使他們的腎臟不能正常的運作。人們的這些蛋白質存在著變異,以及某些變異在以後的生活中可能會使他們的患有腎功能衰竭。腎病蛋白是一拉鏈狀的蛋白、形成裂隙隔膜(濾過裂隙),在這些拉鍊的齒之間存有空間,足夠大到允許糖和水通過,但又裂隙太小以至於不允許蛋白質(白蛋白)通過(防制水腫)。腎病蛋白缺陷對先天性腎功能衰竭負責。CD2AP調節足細胞細胞骨架構及穩定裂隙隔膜。
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).
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