POLD3
Sign in to saveAlso known as P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.
Gene data
POLD3- Name
- DNA polymerase delta 3, accessory subunit
- Type
- protein-coding
- Position
- 74,493,851–74,669,117 (+)
- Aliases
- IMD122, P66, P68, PPP1R128
- Ensembl
- ENSG00000077514
- RefSeq RNA
- NM_001363597.2, NM_006591.3, NR_046409.2, NR_046410.2, XM_005273716.1
- RefSeq protein
- NP_001350526.1, NP_006582.1, XP_005273773.1, XP_011543036.1, XP_047282251.1
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- PDB 1u76 EBI.jpg
Show 5 more facts
- HomoloGene ID
- 38202
- exact match
- identifiers.org/ncbigene/10714
- genomic end
- 74380162
- genomic start
- 74204896
- cytogenetic location
- 11q13.4
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Article
3 sectionsContents
- Interactions
- References
- Further reading
DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.
== Interactions == POLD3 has been shown to interact with PCNA.