polypharmacology
Sign in to savePolypharmacology is the design or use of pharmaceutical agents that act on multiple targets or disease pathways.
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Vinony's link graph records 91 inbound references to polypharmacology, and connects out to International Standard Book Number, digital object identifier and International Standard Serial Number.
It is catalogued under the topic Pharmacology.
Vinony links it to 5 Wikipedia language editions.
Research
1,340 papers- Polypharmacology: The science of multi-targeting molecules.Pharmacological research · 2022
- The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.Neuron · 2025
- Polypharmacology: promises and new drugs in 2022.Pharmacological reports : PR · 2023
- Polypharmacology in the Treatment of Chagas Disease.Current medicinal chemistry · 2019
- Polypharmacology: new drugs in 2023-2024.Pharmacological reports : PR · 2025
via PubMed
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Encyclopedic overview
2 sectionsContents
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Polypharmacology is the design or use of pharmaceutical agents that act on multiple targets or disease pathways.
Despite scientific advancements and an increase of global R&D spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets and the unintended drug-target interactions can cause side effects. Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents. Polypharmacology suggests that more effective drugs can be developed by specifically modulating multiple targets.
Excerpted from Wikipedia’s “polypharmacology” article, available under the CC BY-SA 4.0 licence.