Polypharmacology is the design or use of pharmaceutical agents that act on multiple targets or disease pathways.
via PubMed
Polypharmacology is the design or use of pharmaceutical agents that act on multiple targets or disease pathways.
Despite scientific advancements and an increase of global R&D spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets and the unintended drug-target interactions can cause side effects. Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents. Polypharmacology suggests that more effective drugs can be developed by specifically modulating multiple targets.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).