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Also known as porcupines
Porcupines are large rodents with coats of sharp spines, or quills, that protect them against predators. The term covers two families of animals, the Old World porcupines in the family Hystricidae, and the New World porcupines in the family Erethizontidae. Both families display superficially similar coats of rigid or semirigid quills, which are modified hairs composed of keratin, and belong to the infraorder Hystricognathi within the diverse order Rodentia. The two groups are distinct and are not closely related to each other within the Hystricognathi. The largest species of porcupine is the t
AI overview
Porcupines are large rodents covered with sharp, protective spines called quills that are made of keratin and defend them against predators. There are two distinct families of porcupines—Old World porcupines and New World porcupines—that evolved separately but developed similar quill-covered coats as a defense strategy.
AI-generated from the Wikipedia summary — may contain errors.
Research
983 papers- Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.ReviewPharmacological research · 2021Shah K, Panchal S, Patel BDOI: 10.1016/j.phrs.2021.105532
- Porcupine inhibition enhances hypertrophic cartilage differentiation.JBMR plus · 2025Killinger M, Szotkowská T, Lusková D et al.DOI: 10.1093/jbmrpl/ziaf048
- Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.Acta pharmacologica Sinica · 2023Wu H, Tang LX, Wang XM et al.DOI: 10.1038/s41401-022-01025-y
- Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response.Experimental hematology & oncology · 2024Chen Y, Xiao M, Mo Y et al.DOI: 10.1186/s40164-024-00572-w