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Also known as porcupines
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AI overview
Porcupines are large rodents covered with sharp, protective spines called quills that are made of keratin and defend them against predators. There are two distinct families of porcupines—Old World porcupines and New World porcupines—that evolved separately but developed similar quill-covered coats as a defense strategy.
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Research
983 papers- Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.ReviewPharmacological research · 2021Shah K, Panchal S, Patel BDOI: 10.1016/j.phrs.2021.105532
- Porcupine inhibition enhances hypertrophic cartilage differentiation.JBMR plus · 2025Killinger M, Szotkowská T, Lusková D et al.DOI: 10.1093/jbmrpl/ziaf048
- Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.Acta pharmacologica Sinica · 2023Wu H, Tang LX, Wang XM et al.DOI: 10.1038/s41401-022-01025-y
- Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response.Experimental hematology & oncology · 2024Chen Y, Xiao M, Mo Y et al.DOI: 10.1186/s40164-024-00572-w