POU3F2
Sign in to saveAlso known as N-Oct3, BRN2, OCT7, OTF-7, OTF7, POUF3, brn-2, oct-7
POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.
Gene data
POU3F2- Name
- POU class 3 homeobox 2
- Type
- protein-coding
- Position
- 98,834,574–98,839,458 (+)
- Aliases
- BRN2, N-Oct3, OCT7, OTF-7, OTF7, POUF3, brn-2, oct-7
- Ensembl
- ENSG00000184486
- RefSeq RNA
- NM_005604.4
- RefSeq protein
- NP_005595.2
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
regulation of DNA-templated transcriptionregulation of transcription by RNA polymerase IIregulation of transcription by RNA polymerase IIregulation of transcription by RNA polymerase IInervous system developmentnervous system developmentbrain developmentpositive regulation of cell population proliferation
Molecular function
RNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription activator activity, RNA polymerase II-specificDNA bindingDNA binding
Pathways
Developmental BiologyEGR2 and SOX10-mediated initiation of Schwann cell myelinationNervous system developmentMITF-M-regulated melanocyte developmentRegulation of MITF-M-dependent genes involved in apoptosisTranscriptional and post-translational regulation of MITF-M expression and activityMITF-M-dependent gene expressionMECP2 and Associated Rett SyndromeSudden Infant Death Syndrome (SIDS) Susceptibility Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4095
- exact match
- identifiers.org/ncbigene/5454
- genomic end
- 98839458
- genomic start
- 98834574
- cytogenetic location
- 6q16.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
7 sectionsContents
- Function
- Disease linkage
- Interactions
- See also
- References
- Further reading
- External links
POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.
== Function ==
Connections
Q180686
Entity
human chromosome 6
Entity
Ensembl genome database project
Entity
homeobox
Entity
PDX1
Gene
protein
Entity
Wikidata
Entity
gene
Entity
chromosome
Entity
public domain
Entity
digital object identifier
Entity
bipolar disorder
Entity
bibcode
Entity
human genome
Entity
Q229883
Entity
base pair
Entity
Medical Subject Headings
Entity
locus
Entity
gene expression
Entity
Online Mendelian Inheritance in Man
Entity