Proteolipid protein 1
Sign in to saveAlso known as myelin proteolipid protein, PLP1, major myelin proteolipid protein, lipophilin
mammalian protein found in Homo sapiens
Protein · UniProt
Myelin proteolipid protein
- Gene
- PLP1
- Organism
- Homo sapiens (Human)
- Length
- 277 aa
- Molecular mass
- 30,077 Da
- Evidence
- 1: Evidence at protein level
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin
3D-structureAlternative splicingCell membraneDirect protein sequencingDisease variantDisulfide bondHereditary spastic paraplegiaLeukodystrophy
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
3,954 papers- Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.American journal of physiology. Gastrointestinal and liver physiology · 2023
- Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains.The Journal of clinical investigation · 2023
- Reconstituted Proteoliposome Fusion Mediated by Yeast SNARE-Family Proteins.Methods in molecular biology (Clifton, N.J.) · 2019
- Hemifusomes and interacting proteolipid nanodroplets mediate multi-vesicular body formation.Nature communications · 2025
- Phosphatase and Tensin Homolog Inhibition in Proteolipid Protein 1-Expressing Cells Stimulates Neurogenesis and Gliogenesis in the Postnatal Enteric Nervous System.Biomolecules · 2024
via PubMed
Clinical Trials
11 registered- RECRUITINGRocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher DiseaseIonis Pharmaceuticals, Inc. · NCT05659901
- RECRUITINGLongitudinal Study of Neurodegenerative DisordersUniversity of Pittsburgh · NCT03333200
- PHASE1WITHDRAWNFetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage DiseasesJoanne Kurtzberg, MD · NCT01003912
- PHASE1RECRUITINGUCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like CellsJoanne Kurtzberg, MD · NCT02254863
- PHASE1RECRUITINGOrbit Study: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered ION356 in Participants With Pelizaeus Merzbacher Disease (PMD)Ionis Pharmaceuticals, Inc. · NCT06150716
- NARECRUITINGMesh-Free Versus Mesh-Based Surgery for Female Stress Urinary Incontinence: A Prospective Comparison of Pubo-Urethral Ligament Plication and Transobturator TapeMehmet Incebıyik · NCT07290114
Wikidata facts
- Instance of
- protein
- Image
- Protein PLP1 PDB 2XPG.png
Show 3 more facts
- cell component
- myelin sheath
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P60201
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